New concepts in calcium-sensing receptor pharmacology and signalling

The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology.

The current interest of the scientific community for research in the field of calcium sensing in general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still increasing number of papers published on this topic. The extracellular calcium-sensing receptor is the best-known G-protein-coupled receptor (GPCR) able to sense external Ca2+ changes. Widely recognized as a...

Extracellular Calcium-sensing Receptor Mediated Signalling Is Involved in Human Vascular Smooth Muscle Cell Proliferation and Apoptosis Running Head: Calcium-sensing Receptor Signalling in Vascular Cells

Calcium-sensing receptor (CaSR) plays key role in vascular calcification in patients with chronic kidney disease (CKD). We investigated the role of CaSR in regulating smooth muscle cell (SMC) proliferation and apoptosis. Incubation with 300μM neomycin (CaSR agonist) resulted in 7.5-fold (p<0.05) increase in ERK1,2 phosphorylation. It was reduced (p<0.01) by 10μM PD98059 (MEK1 inhibitor), indica...

CASR (Calcium-Sensing Receptor)

Review on CASR, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

The ORL1 receptor: molecular pharmacology and signalling mechanisms.

The cloning of the opioid-receptor-like 1 (ORL(1)) receptor and the identification of nociceptin as its endogenous agonist have revealed a new G-protein-coupled receptor signalling system. The structural and functional homology of ORL(1) to the opioid receptor systems has posed a number of challenges in understanding the often competing physiological responses elicited by these G-protein-couple...

Calcium, Ca-Sensing Receptor and Breast Cancer